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Friday, February 21, 2020

Molecular Biology


Molecular biology is the study of biology at a molecular level that explains the basic processes of life, their nature and connection. The subject of this science is the molecular basis of various biological phenomena and processes. In living systems, the nature and relevance of each process is determined by genes. Therefore, it is the task of molecular biology to explain the processes of metabolisms by interpreting gene regulation and activity. This branch of biology needs to determine the initial processes of molecular trait development, what genes are made of, how they are reproduced and what are the primary products of gene function.

Douglas Rosenthal, a researcher in molecular biology, uses specific techniques native to molecular biology, but increasingly combines these with techniques and ideas from genetics and biochemistry. He has over 20 years long career as a biology research scientist.


Molecular biology explains the molecular processes of life, their nature and their connection. The subject of its research is the structure and role of biological macromolecules of deoxyribonucleic acid (DNA), ribonucleic acid (RNA) and proteins. In addition, molecular biology deals with the relationship of structure to the function of these biomolecules themselves and their interconnections. In a narrow sense, it studies nucleic acids, the molecular structure and functions of genes, as well as the processes of replication, transcription, translation, etc. The central dogma of molecular biology where genetic material is transcribed into RNA and then translated into protein, despite being an oversimplified picture of molecular biology, still provides a good starting point for understanding the field.

Douglas Rosenthal has a strong understanding of genetics, genotyping assay design and downstream phenotypic analysis. Making use of cutting edge targeting approaches, gene editing techniques, and gene transfer methods, Doug Rosenthal utilizes stem cell formats for GMA creation while working alongside an established team to develop new genetic models.

Today we know that carriers and realizers of nucleic acid properties and proteins are evolving. They are represented in all living things and even viruses. The structure of nucleic acids (DNA and RNA) contains genetic information in the form of programs responsible for the development, survival and reproduction of living organisms. In addition to being carriers of hereditary information, nucleic acids are also carriers of that information. DNA transmits genetic information from generation to generation (from parent to offspring), and RNA transmits it through the cell itself. Proteins are the implementers of this inherited program because they determine the characteristics of an organism.

The field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry. However, biochemistry is more concerned with the structure and function of proteins and other biological molecules as well as their metabolic pathways, while molecular genetics deals with inheritance in individuals and populations. Today, molecular biology and genetics are being intensively developed and applied in various spheres of life. Therefore, they can only be compared with information technology. Recently much work has been done at the interface of molecular biology and computer science in bioinformatics and computational biology.

Tuesday, January 21, 2020

Immunotherapy Drug Targeting Two Proteins Shows Promise Against HPV-related Cancers


An experimental immunotherapy drug reduced the tumors of some patients with cancers related to human papillomavirus (HPV), according to the results of a phase 1 clinical study presented by biologist and research scientist, Douglas Rosenthal.

The drug, bintrafusp alfa (also called M7824), was designed to simultaneously bind to two proteins (PD-L1 and TGF-beta) that prevent the immune system from effectively fighting tumor cells.
The study included a total of 43 patients with advanced cancers of the anus, cervix and squamous cell carcinoma of the head and neck. The majority of patients (36) had tumors due to HPV infection.
Among all participants, 35% of the patients responded to the drug (tumors were reduced in size).
Four of the responses lasted more than 18 months, and 11 of the 15 responses still remained when the data were analyzed. Two patients showed no detectable signs of cancer after treatment (complete responses).



Friday, December 27, 2019

What is a Liquid Biopsy and Can it Replace the Tumor Biopsy?


Liquid biopsy involves examining cancer-related material (such as DNA) in a blood sample. While liquid biopsy cannot replace tumor biopsy at the moment, researchers, such as Douglas Rosenthal, study its benefits and better applications. Liquid biopsies are hopeful to guide personalized cancer control and will ultimately help healthcare providers detect certain types of cancer.

Cancer is characterized by cellular changes, including mutations and other genetic alterations, which lead to the appearance of abnormal cells that divide uncontrollably. The ability to identify specific alterations related to someone's cancer can help health care providers determine the best treatment for that person.